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Jennifer Bandura

Dr. Jennifer Bandura

202 East Campus Science Center
(570) 484-2524

Courses Most Commonly Taught

  • Basic Biology Lab
  • Principles of Biology Lab
  • Cancer Biology

Areas of Expertise

  • Cell Biology
  • Cell Division
  • Fruit Fly Genetics
  • Molecular Biology

The overall goal of my research is to understand the mechanisms that control changes in cell division during development.  Understanding why cells to divide, or stop dividing, at particular points in development will help us to better understand the production of healthy tissues, and also the aberrant cell proliferation that leads to cancer.  Specifically, I study cell division in Drosophila melanogaster (fruit flies).  Drosophila is an excellent model system for studying cell division because flies possess cell cycle controls similar to those in humans.  In addition, there are many powerful genetic and cell biological tools available in flies that can be used for experiments.

Education

  • Postdoctoral Researcher, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Postdoctoral Researcher, Fred Hutchinson Cancer Research Center, Seattle, WA
  • Ph.D. Cell and Molecular Biology, University of Pennsylvania
    Dissertation:  humpty dumpty defines a new gene family required for S phase
  • B.S. Biological Sciences with a concentration in Genetics, Cornell University

Courses Developed

  • Cancer Biology

Professional Publications

Lesly, S., J.L. Bandura, and B.R. Calvi. 2017. Rapid DNA synthesis during early Drosophila embryogenesis is sensitive to maternal Humpty Dumpty protein function. Genetics. 207(3):935-947.

Bandura, J.L. and N. Zielke. 2017. Polyploidy in animal development and disease. In Somatic Genome Variation. Xiu-Qing Li, editor. Wiley-Blackwell, Hoboken, NJ. 3-44.

Xiang, J., J. Bandura, P. Zhang, Y. Jin, H. Reuter, and B.A. Edgar. 2017. EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration. Nature Communications. 8:15125. doi: 10.1038/ncomms15125.

Bandura, J.L., H. Jiang, D.W. Nickerson, and B.A. Edgar. 2013. The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster. PLoS Genetics. 9(9): e1003835. doi:10.1371/journal.pgen.1003835.

Bandura, J.L. and B.A. Edgar. 2008. Yorkie and Scalloped: partners in growth activation. Developmental Cell. 14(3):315-316.

Bandura, J.L., E.L. Beall, M. Bell, H.R. Silver, M.R. Botchan, and B.R. Calvi. 2005. humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Current Biology. 15:755-759.

Bandura, J.L. and B.R. Calvi. 2002. Duplication of the genome in normal and cancer cell cycles. Cancer Biology and Therapy. 1(1):8-13.

Kwiatkowski, D.J., H. Zhang, J.L. Bandura, K.M. Heiberger, M. Glogauer, N. el-Hashemite, and H. Onda. 2002. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Human Molecular Genetics. 11(5):525-534.

Marks, P.W., J.L. Bandura, D.-B. Shieh, D. Foernzler, D.R. Beier, and D.J. Kwiatkowski. 1999. The spontaneous coat color mutant white nose (wn) maps to murine chromosome 15. Mammalian Genome. 10(7):750-752.

Marks, P.W., M. Arai, J.L. Bandura, and D.J. Kwiatkowski. 1998. Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins. Journal of Cell Science. 111( Pt 15):2129-2136.

 

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